Abstract

CURRENT APPROACHES ON GASTRO RETENTIVE DRUG DELIVERY SYSTEM: AN OVERVIEW

Gunjan Gadge*, Vidya Sabale, Ankita Khade and Ujwala Mahajan

ABSTRACT

Gastro retentive drug delivery system (GRDDS) can be defined as a system which remains in the stomach for a sufficient time period and releases active ingredients in a controlled manner. This, significantly extends the duration of drug release, prolongs dosing interval and increases bioavailability of drugs and therefore improves compliance of the patients and effectiveness of pharmacotherapy. The current review deals with the advantages, disadvantages, parameters-affecting gastric emptying, formulation considerations, factors that affect gastro retentive systems and also highlights some of the recent gastro retentive approaches. Recent approaches to increase the gastric residence time of drug delivery systems include bioadhesive systems, floating systems (low density systems), non-floating systems (high density systems), magnetic systems, swelling systems, unfoldable and expandable systems, raft forming systems and superporous systems, biodegradable hydrogel systems. The main emphasis is on the entire classification and different types of GRDDS. Finally evaluation methods of these systems have been summarized.

Keywords: GRDDS, Bioavailability, Gastric emptying, Superporous Systems.