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Abstract

COMPARATIVE EVALUATION OF SUPERDISINTEGRANT AND SUBLIMATION METHOD FOR FORMULATION OF PANTOPRAZOLE SODIUM SESQUEHYDRATE MOUTH DISSOLVING TABLETS

Talat Nahid, Nimisha*

ABSTRACT

The purpose of this research work was to develop mouth dissolving tablets of Pantoprazole sodium sesquehydrate by superdisintegrant addition and sublimation method .Pantoprazole sodium sesquehydrate is a selective and potent proton pump inhibitor. It has poor bioavailability of 50% and poor aqueous solubility and thus makes its absorption and dissolution rate limited, delaying its onset of action. Sodium starch glycolate was used as super disintregrant and camphor used for enhancement of porosity of the tablets. Disintegration time of tablets prepared by superdisintegrant addition were significantly less (p<0.05) than prepared by sublimation technique hence it was selected for further study. Tablets were evaluated for weight variation, thickness, hardness, friability, drug content, disintegration time. All tablet batches passesss evaluation parameters. The physical properties of the prepared tablets did not show any significant variations (p>0.05) and were found to have good physical integrity. Stability studies showed that the physical and chemical properties of the tested tablets were not altered significantly and all the test formulations were found to be stable. The dissolution profile of fresh and aged Pantoprazole sodium sesquehydrate MDT showed no significant effect on drug release (p> 0.05).

Keywords: Mouth dissolving tablets, Camphor, Sublimation method, Superdisintegrant addition method.


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