Abstract

2, 5- DISUBSTITUTED 1,3,4-THIADIAZOLES: MOLECULES OF MANIFOLD APPLICATIONS – A REVIEW

Dr. Annapoorna Vadivelu*, A. NAzreen Banu, Y. Nafoura B. Egam and P. Madhivardhana

ABSTRACT

1,3,4-thiadiazole is an example for motley moiety, which on substitution with its bioisosteres such as oxadiazole, oxazole and benzene leads to increase n its pharmacological activity. The unique chemical properties and biological activity of 1,3,4-thiadiazoles make them as attractive targets for the medicinal chemists. 1,3,4-thiadiazole nucleus represent an excellent pharmacophore with diverse activititessuch as antimicrobial, anti-tubercular, anticancer, CNS depressant, antioxidant, antiviral, antidiabetic and hypertensive etc. The review presents a brief summary of the chemistry, synthesis and a broad view on the various pharmacological activities possessed by different compounds substituted with 1,3,4-thiadiazole nucleus.

Keywords: 2,5-disubstituted 1,3,4-thiadiazoles, Reactivity, Methods, Pharmacological activity.