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Most. Naoshia Tasnin, Ariful Islam, Monirul Islam, Md. Ismail Hossain, Md. Matiar Rahman and Md. Amirul Islam*


Diabetes mellitus (DM) is a serious metabolic disorder and plenty of medicinal plants are used in traditional medicines to treat diabetes. Abnormality in levels of blood glucose, lipid profile, SGPT, SGOT, and CRP levels are common characteristic of DM. Allium sativum (AS), seeds of Nigella Sativa (NS) and Trigonella foenum-graecum (TF) have antidiabetic property as reported previously, but they didn’t get sufficient acceptance by the people as supplementation for the treatment of DM due to their bad orders and tastes. To address this problem, our present study was undertaken to investigate the antidiabetic activity of a mixed herbal food (MHF; mixture of NS, AS, TF, and pure honey in equal proportion) using experimentally induced DM rat model. DM was induced by a single intraperitoneal injection of alloxan (90 mg⁄kg body weight). Dietary supplementation of MHF reduced the blood glucose levels by 22.85%-59.06% (P<0.01) in 7th to 28th days, alleviated parameters of lipid profile significantly (P<0.01) in diabetic rats compared to the diabetic control rats. Moreover, MHF regulated SGPT, SGOT and CRP levels in diabetic rats significantly (P<0.01), and recovered hepatic injury. In conclusion, MHF has significant antidiabetic property and it may play a potential role to treat DM.

Keywords: Diabetes mellitus, Antidiabetic activity, Mixed herbal food, Lipid profile, Hepatic injury.

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