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Abstract

PHYSICAL AND ANALYTICAL EVALUATION OF DIFFERENT BRANDS OF DIAZEPAM 5 MG TABLET AVAILABLE IN BANGLADESH

Md. Shamsuzzaman**, Md. Rahimul Hasan* and Md. Taslim Alam*

ABSTRACT

A major concern to the pharmaceutical industries is the quality of pharmaceutical finished dosage forms. The development of any pharmaceutical product is to maintain the quality standard of the product which is an important aspect. Through a variety of directions, pharmaceutical preparations take many shapes and forms and are well organized. Oral solid dosage forms remarkably the tablet dosage form is the most prominent of all. Many research studies and experiments to maintain the proper quality standards of the tablet dosage form of any pharmaceutical company has to go through a lot. To ensure quality product different level of tests are done. Diazepam is a drug which has effects on the central nervous system. The purpose of this study which is to investigate the status of different brands of diazepam tablets are manufactured in Bangladesh and because of this investigation the researchers find out that such tablets give better pharmacological action, should not yield noxiousness and the universal image of a tablet, its apparent individuality, and entire grace is requisite for consumer assent. Incompatible physical limitations such as stiffness, expanse, frailty as well as dissolution time were led to assess the character of the tablets of various brands of diazepam. The scale of the stiffness test result was 4.7-9.0 kg. This research work was aimed to investigate the quality control parameters of five brands of diazepam (Seduxen®, Sedil® D-Pam®, Evalin®, Easium®) which are available in the market. This, in turn, helps to determine whether the five brands of diazepam were manufactured according to the specifications given by British Pharmacopeia (BP). The five brands of diazepam were collected from local market of Bangladesh. Then the brands were subjected to physical parameter tests such as weight variation, hardness, thickness, friability, and disintegration. The brands passed the tests as no tablets cross the ±7.5% weight variation. All the 50 tablets of both the brands disintegrated within 15 minutes and thus they complied with the specifications. Last but not least it can be concluded that five brands of diazepam were manufactured according to the specifications given by British Pharmacopeia (BP). we have done other tests required for the determination of the quality control parameters which have shown satisfactory results.

Keywords: Bangladesh, Diazepam tablet, disintegration, dissolution.


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