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Abstract

PREPARATION AND EVALUATION OF TRANSDERMAL PATCHES OF METFORMIN TABLET

Km. Lavi Garg*

ABSTRACT

With the advancement in technology Pharma industries have trendified all its resources. Earlier we use convectional dosage form but now we use novel drug delivery system. One of greatest innovation of novel drug delivery is transdermal patch. The advantage of transdermal drug delivery system is that it is painless technique of administration of drugs. Skin is used for the delivery of drug because skin has large surface area, there is systemic access through underlying circulatory and lymphatic networks and it is the non invasive nature of drug delivery. This route of drug delivery was invented in 1981when Ciba Geigy marketed Transderm V which is now called as Transderm Scop to cure nausea and vomiting associated with motion sickness. The main advantage of transdermal drug delivery system is controlled release of the drug into the patient, it enables a steady blood level profile, resulting in reduced systemic side effects and, sometimes, improved efficacy over other dosage forms. The main objective of transdermal drug delivery system is to deliver drugs into systemic circulation through skin at predetermined rate with minimal inter and intra patient variation. In this paper we have covered what are transdermal patch, it’s uses, limitation, factor affecting transdermal drug delivery system, component of transdermal drug delivery system, penetration enhancers methods and evaluation of transdermal drug delivery system.

Keywords: Transdermal drug delivery systems (TDDS), Polymer Matrix, Permeation enhancers, Iontophoresis.


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