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Abstract

FORMULATION AND CHARACTERIZATION OF SUSTAINED RELEASE MATRIX TABLETS OF VERAPAMIL HYDROCHLORIDE USING SYNTHETIC, SEMI-SYNTHETIC AND NATURAL POLYMER

Kusuma Anusha*, Velpula Kalyani and Kola Venu

ABSTRACT

Objective: Formulation and characterization of sustained release matrix tablets of Verapamil hydrochloride using synthetic, semi-synthetic and natural polymer. Methods: Matrix tablets of Verapamil hydrochloride with natural, semi synthetic and synthetic polymer were prepared by direct compression method and prepared tablets were evaluated for their physical properties, weight variation, friability, hardness, thickness, and In-vitro dissolution and kinetics of drug release. Optimized formulation was compared with marketed oral tablets. Results: In Optimized formulation (F9), synthetic polymer HPMC K100 was used in combination with Semi-synthetic polymer CMEC individually. The drug release was found to be 98.7% at 24hr. Formulation (F9) was shown desired release profile for sustained drug delivery up to 24 h. which is better than the release rate of marketed Calaptin i.e. 93.19% (up to 12 hrs.) optimized formulation hardness friability, drug content, thickness was found to be optimum. The IR spectra study revealed no physical and chemical interaction in the compatibility between the drug and the other formulation components. Conclusion: The results of the in vitro characteristics showed that formulation F9 having synthetic and semi-synthetic polymers in combination showed better results. The results of the formulation F9 were compared with the Calaptin 120 SRĀ® and better action was found.

Keywords: Verapamil hydrochloride, matrix tablet, HPMC K100, CMEC, sustained release.


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