Abstract

FORMULATION AND EVALUATION OF FLOATING EFFERVESCENT TABLETS OF RAMIPRIL

*Khan Mohd. Faarooq, Dr. Sharma Vimukhta and Umesh Atneriya

ABSTRACT

Ramipril is antihypertensive prodrug which belongs to the category angiotensin-converting enzyme (ACE) inhibitor class. In Liver it is metabolized to ramiprilat in the liver. Ramiprilat is a potent, competitive inhibitor of ACE. This research is designed to develop a dosage form which retains in the stomach for longer time and the release of which is prolonged. Effervescent Floating tablets containing Ramipril were prepared in different batches i.e. F1 to F9 by direct compression technique using varying concentrations of different grades of polymer with Sodium bicarbonate and citric acid. Fomulation of effervescent tablets were evaluated by drug characterization and identification by Physical appearance, Melting point, FTIR which identified the purity of drug. Preformulation studies was done by preparation of calibration curve. Post compression evaluation was done by Drug content, Buoyancy lag time (BLT), Total floating time, Drug release study,in-vitro drug release. In vitro release studies of F1 to F9 formulations of Ramipril were carried out in the dissolution test apparatus (USP Type II). It is, thus concluded that effervescent floating tablet containing Ramipril (F9 formulation) gave slow and complete drug release spread over 20 hours. Thus F9 formulation was said to be optimized formulation. Stability study and others thickness, diameter,hardness, friability and weight of variation were also done. The spectrum thus obtained was compared with reference spectrum of Ramipril. The FT-IR spectra for pure drug was obtained by power diffuse reflectance on a FT-IR spectrophotometer in the wave number region of 4000-400 cm-1. The UV spectroscopy of ramipril exhibited absorbance maxima (λmax) at 231 nm in 6.8 pH buffer. The results obtained may be considered as tools for the manufacturer of standard formulation with great efficacy.

Keywords: Ramipril, effervescent, floating, Tablet, FDDS, HPMC, formulation.