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Surya Punjabi, Abhishek Verma, Manisha Malik, Himanshu Sharma, Pallavi Sharma and Himanshu Thukral*


Dental implants have become a routinely used technique in dentistry for replacing teeth. However, risks of failure are still experienced and remain difficult to anticipate. Multiscale phenomena occurring around the implant interface determine the implant outcome. The implant-to-bone interface is an extremely dynamic region of interaction. Generally, a surgical procedure is performed on a patient to insert a foreign material into the bone, and the body is called on to “heal” the wound. The time schedule crucial for a healing process that is expected to result in restitution ad integrum must be determined with respect to the condition of the individual patient and tissue to be treated. There are various factors responsible for the formation of an adequate bone–implant interface. The aim of this review is to provide an understanding of the biomechanical behavior of the interface between a dental implant and the region of bone adjacent to it (the bone–implant interface) as a function of the interface's environment. First, we describe the determinants of implant stability in relation to the different multiscale simulation approaches used to model the evolution of the bone–implant interface. Then, we review the various aspects of osseointegration in relation to implant stability. A comprehensive review of the response of bone to implant is described.

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