Abstract

RECENT ADVANCES IN GRANULATION TECHNOLOGIES

Harshada S. Chaudhari*, Vidya P. Sable, Ujwala N. Mahajan

ABSTRACT

The process of granulation is to transform fine powders into free-flowing, dust-free granules that are easy to compress. During preparing granules numerous challenges, we need to overcome due to a high-quality requirement of the formed granules in terms of content uniformity and physicochemical properties such as granule size, bulk density, porosity, hardness, moisture, compressibility, etc. and also together with physical and chemical stability of the drug. Granulation process can be divided into two types: dry granulation that requires no liquid and wet granulation that utilize a liquid in the form of granulating fluids. The type of process selection requires a thorough knowledge of physicochemical properties of the drug, excipients, required flow and release properties. Conventionally, roller compaction and slugging are types of dry granulation. On the other side, in wet granulation low shear mixing, high shear mixing, and fluid bed granulation are present. As like any other scientific field, pharmaceutical granulation technology also continues to change, and the arrival of the novel and innovative technologies. Recent progress in the granulation techniques and technologies such as in dry granulations, pneumatic dry granulation. In wet granulation wide range of innovations like reverse wet granulation, steam granulation, moisture-activated dry granulation, thermal adhesion granulation, freeze granulation, and foamed binder or foam granulation.

Keywords: Granulation technologies, dry granulation, wet granulation.