Abstract

PATTERNS OF ANTIBIOTIC USE IN CHRONIC KIDNEY DISEASE PATIENTS

Olivia J. Xavier*, Amulya M. K., Jaya Nepal, Aashutosh Mishra, Mahadevamma L. and K. A. Sridhar

ABSTRACT

Background: Chronic kidney disease (CKD) is a progressive loss of renal function, characterized by gradual replacement of normal kidney architecture with interstitial fibrosis. Appropriate antibiotic choice would maximize efficacy and minimize toxicity and reduces the incidence of adr, improve treatment success and reduce hospital admission and even mortality. Objectives: Patterns of Antibiotic Use in Chronic Kidney Disease patient. Methodology: Based on the inclusion & exclusion criteria, 200 patients were subjected for prospective and observational studies. Studies data has been evaluated and statistically reported by SPSS software 20.0 ver. Result: The most prescribed antibiotics were piperacillin + Tazobactam, ceftriaxone and amoxicillin + clavulanate. The least prescribed antibiotics were amikacin, cefazidime and clarithromycin. The highly prescribed fixed dose combination was Piperacillin + tazobactum & fixed dosages were 4gm and 500mg respectively. Cefoperazone with furosemide showed most occurred drug interactions with 8.2%. All the datas were significantly reported and found to be 0.05%. Conclusion: The data suggests that the professionals must understand the antibiotic usage for specific conditions in CKD patients so as to minimize the adr, drug interactions and treatment cost of antibiotic use. The number of antibiotics prescribed to these patients must be minimized so as to reduce toxic effects involved in excessive use of antibiotics.

Keywords: Chronic Kidney Disease, Antibiotics, Drug- drug interactions.