Abstract

WASP POLISTES FLAVUS VENOM INDUCED GOT AND GPT ALTERATIONS IN THE SERUM, LIVER AND MUSCLES OF ALBINO MICE

Krishna Kumar Prajapati and Ravi Kant Upadhyay*

ABSTRACT

Objective: Enzymatic effects of purified wasp venom toxins on transaminase enzymes activity in blood serum, liver and gastrocnemius muscle tissue of albino mice. Method: Determination of the lethality dose of purified Polistes flavus venom toxins. After administration of sub-lethal dose activity of transaminase enzymes were measured. Results: In the present investigation activity of GOT and GPT alterations in the serum, liver and muscles of albino mice after injection of sub-lethal dose of purified Polistes flavus venom toxins to the albino mice. Coclusion: A significant elevation was observed in serum glutamate pyruvate transaminase, glutamate oxaloacetate transaminase activity. Both enzymes i.e., Glutamate pyruvate transaminase, glutamate oxaloacetate transaminase are cellular metabolic enzymes with no evident function in vertebrate plasma. These enzymes also occur in small concentrations in plasma, which may be delivered from the regular physiological shedding of cells.

Keywords: Serum, Liver and Gastrocnemius muscles (G. muscles), GPT and GOT.