Abstract

EFFECT OF CIPROFLOXACIN ON THE MICROARCHITECTURE OF THE OSSEOUS TISSUE

*Uloneme Godwin Chinedu, Akukwu, Cyprian Darlington, Ekezie Jervas Nwankpa Promise and Alagwu Emmanuel

ABSTRACT

Ciprofloxacin is a drug of choice widely used for the treatment of a wide range of bacterial infections in Nigeria. This study whose span was about six months investigated the effects of ciprofloxacin on the skeletal microarchitecture of albino wister rats. A total of forty albino wister rats (each weighing about 200g) identified as group A,B,C and D. Each group consisted of ten rats. While group „A‟ rats isolated as the control group was fed with rat chow satisfactorily and then administered only distilled water, the other groups (B,C, and D) were the experimental animals fed with rat chow ad libitum, and then administered varying and corresponding doses of the drug (ciprofloxacin) Bis in Die(bid) daily for six consecutive weeks under good environmental conditions through oral intubations. Groups B,C, and D animals were given daily doses of 0.8mg/kg body weight, 1.6mg/kg body weight and 3.2mg/kg body weight respectively. The animals were sacrificed after six weeks of treatment and their tibial bones were harvested and taken to the laboratory for histological investigations. The result obtained revealed that high dosage of ciprofloxacin caused bone resorption and reduced bone formation which led to depletion in the microarchitectural status of the bone tissues investigated.

Keywords: Ciprofloxacin, Osseous tissue, Antibiotics, Wister rats, Microarchitechture.