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Abstract

DEVELOPMENT AND VALIDATION OF SIMPLE UV SPECTROSCOPIC METHOD FOR THE ESTIMATION OF MARKETED DOXORUBICIN FORMULATION

Srikanth*, Anand Kumar Y, Mallikarjuna Setty C and Mohammed Parvez Ahmed

ABSTRACT

Doxorubicin an anthracycline antibiotic has been used for decades for treatment of various types of cancers while providing a cure in a good degree of cases. In the present study simple, rapid, accurate UV spectrophotometric method were developed and validated for the estimation of Doxorubicin in bulk and its formulations as per ICH guidelines. Three solvent systems viz., Distilled water, 0.1N HCl and 0.1N HCl : Methanol (1:1) were tried. The results suggest that the developed methods shows linearity over the concentration range of 1-10μg/ml with a correlation coefficient of 0.9999. All the developed methods were statistically validated for accuracy, precision, linearity, robustness, and roggadness as per ICH guidelines. The % RSD values for validated methods were found to less than 1.5 and methods will find application in routine analysis of drug formulations containing doxorubicin.

Keywords: Doxorubicin, UV-spectrophotometric, Distilled water, 0.1N HCl and 0.1N HCl: Methanol (1:1).


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