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Abstract

DEVELOPMENT AND CHARACTERIZATION OF CONTROLLED RELEASE MATRIX TABLET OF TIAGABINE HYDROCHLORIDE

Akib Y. Mansuri*, Dr.Anand K. Patel and Dr. Vishnu M. Patel

ABSTRACT

The aim of the present study was to develop and characterization of the controlled release matrix tablets of tiagabine. Tiagabine is a nipecotic acid derivatives and anticonvulsant medicament used for the treatment of partial seizures in adults and children ≥12 years of age. FTIR studies indicated no interaction between drug and excipients. All the parameters showed good results. The result was found to be that among the nine formulation the Z4 formulation was found to be the best as it shows maximum drug release of 98.96% at 24 hours. It was subjected to accelerated stability studies for one month. The formulation was found to be stable. It concludes that the controlled release matrix tablets of Tiagabine can prepared by direct compression. Among all the formulations (Z1 to Z9) the Z4 formulation was found to be the best formulation. It showed the least of 25.84% drug release within 2 hours.

Keywords: Tiagabine, Controlled Release tablet, Hydroxy propyl methyl cellulose, Polyethylene oxide, Guargum, direct compression.


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