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Abstract

SYNTHESIS AND ANTI-INFLAMMATORY ACTIVITY SCREENING OF SOME NOVEL PYRAZOLE DERIVATIVES

Pratap Kumar Patra*, Ch. Niranjan Patra, Subasini Pattnaik

ABSTRACT

The Inflammation is a serious health problem in industrialized country due increase in pollution. In the present study a series of new pyrazole clubbed with quinazolinone compounds (7a1-2, 7b1-2) were synthesized and were evaluated for their anti-inflammatory activity by using the model of carrageenan induced mice paw edema in adult albino rat on comparison with standard diclofenac. The maximum antiinflammatory activity was recorded by the compound 7a1 having 65.38% percentage protection of edema followed by compound 7b1 (60.25 %), 7b2 (50 %) & 7a2 (39.74%) anti-inflammatory potential. The compound 7a1 showed more percentage protection of edema than that of standard drug Diclofenac sodium. It has been found that the extent of increase in paw volume reduces significantly up to 3 hrs when compared with solvent control.

Keywords: Anti-inflammatory activity, Carrageenan induced mice paw edema, Diclofenac, Pyrazole, Quinazolinone.


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