Abstract

FORMULATION AND EVALUATION OF SUSTAINED RELEASE MATRIX TABLETS OF ISONIAZID

Vicky Kumar*, Dr. Prashant Upadhyay and Kuldeep Kesri

ABSTRACT

The present examination reports the advancement and in vitro assessment of gastro retentive Sustained discharge network tablets of Isoniazid. The details were created utilizing excipients, for example, HPMC K100 and Di-calcium Phosphate in various proportion. Portrayal was completed by Fourier Transform Infrared (FTIR) Spectroscopy bright (UV) Spectroscopy, Differential examining calorimetry (DSC). The FTIR and UV thinks about proposed that no bond arrangement had happened between the polymer and the medication. DSC results discounted any association or complex arrangement between the medication and the polymer which discharged the medication over an all-encompassing time of over eight hours. Supported discharge tablets were set up by Wet Granulation technique. The definitions were exposed to different assessment parameters, for example, Drug Excipient Compatibilities Studies, Angle of Repose, Bulk Density, Hardness, Friability, Drug content consistency, Wetting time, in vitro disintegration thinks about, Curve fitting examination. Every one of the details were great in appearance and indicated better physical and mechanical properties. In light of AIC esteem Formulation F1 and F2 pursue the zero request models and F3 pursue the korsmeyer peppas display demonstrating that sedate is inadequately solvent in framework dose structure. As indicated by figuring the n estimation of all plans are higher than 0.89. So these plans pursue the super case II transport Mechanism of discharge.

Keywords: Isoniazid, HPMC K-100, Dicalcium Phosphate.