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Abstract

DISSOLUTION RATE ENHANCEMENT OF KETOCONAZOLE BY SPHERICAL AGGLOMERATION

Rekha P. Mudke*, Sonali N. Koli, Varsha S. Tegeli, Yogesh S. Thorat, Avinash H. Hosmani

ABSTRACT

The purpose of this study was to enhance the dissolution rate of poorly water soluble drug of Ketoconazole by preparing spherical agglomerates by Quassi emulsion solvent diffusion technique using chloroform, water, and methanol as bridging liquid and to illustrate the effect of different polymers on the solubility and dissolution rate of Ketoconazole. Polyvinyl Pyrrolidone (PVP K30) was used in spherical agglomeration process. The formulation was done by 32-full factorial design. Stirring speed and the concentration of PVP K30 were used as the variable factors in the applied design. Fourier Transform Infra-Red spectroscopy was used to examine the drug-excipient compatibility. Prepared formulations were evaluated for micromeretic properties and dissolution rate. The spherical agglomerates have lower micrometric properties compared to pure drug. The agglomerates exhibited good compressibility and packability characteristics. The spherical agglomerates with different polymers exhibited increasing in the saturation solubility and dissolution rate.

Keywords: Ketoconazole, Agglomerates, dissolution, Polyvinyl Pyrrolidone (PVP K30).


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