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Abstract

FORMULATION AND EVALUATION OF TOPICAL ANTIFUNGAL GEL CONTAINING FLUCONAZOLE

Krishnamurthy A. Kamlapurkar, Manmat B. Rumane*, Shrishail M. Ghurghure, Naushad N. Mirza, Sagar S. Sontakke, Aniket S. Katte and Akshay R. Kale

ABSTRACT

The aim of the study was to formulate and evaluate fluconazole topical antifungal gel. Fluconazole is an imidazole derivative and used for the treatment of local and systemic fungal infection. The oral use of Fluconazole is not much recommended as it has many side effects. Fluconazole topical gel preparation are not available in the market, thus this formulation is made for better patient compliance and to reduce the dose of the drug and to avoid the side effects like liver damage and kidney damage. FT-IR study confirmed the purity of drug and polymers. Fluconazole topical gel was formulated by different polymers with different ratios such as Carbopol 971p and noveon AA1 in the concentration of 1% and 1.5% respectively. DMSO was used as penetration enhancer. Formulated gel was characterized for drug content, pH determination, viscosity measurement, spreadability, extrudability, in vitro diffusion and anti fungal activity. The pH of all formulations lies between the normal pH range of the skin. Drug content results concluded that the uniform drug distributionthroughout the gel formulation. The in vitro diffusion of batch F3 give highest drug release.

Keywords: Fluconazole, Noveon AA1, Carbopol 971p, Topical Gel, Antifungal activity.


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