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Abstract

UV- SPECTROPHOTOMETRIC METHOD DEVELOPMENT AND VALIDATION FOR DETERMINATION OF CHLORTHALIDONE IN BULK AND PHARMACEUTICAL DOSAGE FORM

Shubhangi Sidram Bamgonde*, Dr. Mallinath Shankarappa Kalshetti, Kaveri Chandrant Dulange, Zeba Mahamad Hanif Gaibu and Neha Ranjeet Gate

ABSTRACT

A rapid, simple, selective, sensitive, precise and specific UV Spectrophotometric method has been developed for the determination of Chlorthalidone in bulk and (200-400nm) in 1cm quartz cell in a double beam UV Spectrophotometer. The spectrophotometric detection was carried out at an absorption maximum of 227 nm using Methanol as solvent. The detector response for the Chlorthalidone was linear over the selected concentration range 2-10 μg /ml with a correlation coefficient of 0.999 and equation for the regression curve was found to be y=0.071x+0.182. The accuracy was between 97-100 %. The precision (%RSD) among six samples preparation was 0.160 %. The LOD and LOQ was 0.251 And 0.3200 μg /ml respectively. Statistical analysis proved that the methods are repeatable and specific for the determination of the said drug. These methods can be adopted in the routine assay analysis of Chlorthalidone in API and pharmaceutical dosage form.

Keywords: Chlorthalidone, UV Spectrophotometer, Methanol, Method Validation.


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