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Abstract

FORMULATION AND EVALUATION OF MICROEMULSION CONTAINING NEEM SEED OIL

Prof. Krishnmurthy A. Kamlapurkar, Manmat B. Rumane*, Naushad N. Mirza, Aniket S. Katte, Akash A. Patil and Akshay R. kale.

ABSTRACT

The objective of present study was to formulate Microemulsion containing Neem seed oil. Neem seed (Azadirachta indica) oil was extracted from its seeds by soxhlet apparatus. Acetone is used as solvent. Tween 80, PEG 400 and Carbopol 940p and Xanthan gum were selected as surfactant, co-surfactant and hydrogel thickening agent respectively. Microemulsions were characterized for pH, viscosity, spreadability, in vitro drug transport study and in vivo anti bacterial activity and shows satisfactory results. The in-vitro study was performed and batches with carbopol 940 shows highest drug release. Antibacterial activity of formulation against E. coli Shows at concentration of 3%. Study reveales that Neem seed oil microemulsion has potential for antibacterial activity and used as topical preparation.

Keywords: Neem seed oil, Microemulsion, Topical application, Antibacterial activity.


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