Abstract

STUDY ON COMPARISON OF VARIOUS DRUG COMBINATIONS USED IN PREVENTION OF PRIMARY POSTPARTUM HEMORRHAGE

Ibtesam, Sadia Fatima and Adeeba Zahoor

ABSTRACT

Objective: To compare the effectiveness of various drug combinations used for the prevention of primary postpartum hemorrhage. Methods: A Hospital based prospective observational study was carried out for a period of six months in the Gynecology and obstetrics department of a multispecialty hospital. Patient’s data collection forms were designed and the data was recorded. Results: It was found that the combination of oxytocin and misoprostol alone was not enough for the prevention of primary postpartum hemorrhage in most of the cases. Other prophylactic uterotonics like carboprost, methylergonovine and drugs like tranexamic acid are being used in combination with oxytocin and misoprostol. It was found that majority of the patients, about 72.80% (n=83) who had developed PPH were given the combination of oxytocin and misoprostol (O+M) prophylactically. Least occurrence of PPH was observed in 0.87% (n=1) of patients when the combination of oxytocin, misoprostol and methylergonovine (O+M+METH) was administered prophylactically. Conclusion: The selection of an effective prophylactic uterotonic drug combination in accordance with the risk factors of individual patients is necessary for the prevention of PPH.

Keywords: Postpartum hemorrhage. Uterotonic. Prevention.