Abstract

FLOATING DRUG DELIVERY SYSTEMS: A REVIEW

Amrita Bisht, Priyanka Gupta and Dr. N. G. Raghavendra Rao*

ABSTRACT

Recent technological and scientific research has been devoted to the development of rate controlled drug delivery systems to overcome physiological adversities such as short gastric residence times and unpredictable gastric emptying times. Differences in gastric physiology such as gastric pH and motility exhibit both intra and inter subject variability demonstrating significant impact on gastric residence time and drug delivery behavior. Pharmaceutical industries have received much interest in pharmaceutical research in the area of oral drug delivery more over on Gastro retentive drug delivery system that is Floating Drug Delivery System (FDDS).The objective of this study to review on FDDS focusing on its current advancement and its future. The purpose of writing this review on floating drug delivery systems (FDDS) was to compile the recent literature with special focus on the principal mechanism of floatation to achieve gastric retention. The recent developments of FDDS including the physiological and formulation variables affecting gastric retention, approaches to design single-unit and multiple-unit floating systems, and their classification and formulation aspects are covered in detail This review article is in pursuit of giving detailed information on the pharmaceutical basis of their design, classification, advantages and disadvantages, factors affecting gastric residence time of FDDS, applications, and formulation of floating tablet. Floating drug delivery systems improves the drug bioavailability and patient compliance by increasing the gastric residence time and controlling the drug release. In this review, the technological and research advancements made in floating systems are discussed.

Keywords: Floating drug delivery system, Gastric residence time, bioavailability, Swelling index, Buoyancy time.