Abstract

MICROBALLOONS: A MODERENSTICS APPROACH FOR GASTRO RETENTIVE DRUG DELIVERY SYSTEM- A REVIEW

Swati Gupta*, Anita Singh and Dr. Satish K. Sharma

ABSTRACT

The aim of writing this review on microballoons is to assemble the recent literature with special focus on the novel advancements in floating drug delivery system to achieve gastric retention. Gastric emptying is a complex process and makes in vivo performance of the drug delivery systems uncertain. In order to avoid this variability, efforts have been made to increase the retention time of the drug-delivery systems for more than 12 hours. The Microballoons delivery systems are useful in such application. Microballoons (Hollow microsphere) promises to be a prospective approach for gastric retention. Microballoons drug delivery systems are based on non -effervescent system. Microballoons are spherical empty particles without core ideally having a size less than 200 micrometer. They are gastroretentive drug delivery systems which provide controlled release properties. The advantages, limitation, applications, list of polymers used in hollow microspheres, characterization of microballons and formulation aspects are covered in detail.

Keywords: Microballoons (Hollow Microspheres), Gastroretentive, Gastric time, Gastric emptying, Buoyancy.