Abstract

CHEMO-SUPPRESSIVE ACTIVITIES OF CLOTRIMAZOLE AND GABAPENTIN IN A MURINE MALARIAL MODEL

Ayankunle A. A.*, Wakeel O. K., Kolawole O. T., Ojurongbe O., Adeyeba O. A.

ABSTRACT

AIM: To assess the chemo-suppressive activities of clotrimazole and gabapentin in a murine malarial model by four-day suppressive test. STUDY DURATION: This study was done between June and December, 2017. METHOD: Clotrimazole (CLT), gabapentin (GBP), combination of clotrimazole and gabapentin (CLT+GBP), dihydroartemisinin-piperaquine (DHP) and DMSO 5% v/v were administered to infected mice, from 24 hours post parasitic inoculation respectively. Average percentage parasitemia (%parasitemia) and percentage chemo-suppression (%chemo-suppression) were calculated separately for day-4 and day-7. RESULTS: Each of treated groups had longer survival days and significant (p

Keywords: AIM: To assess the chemo-suppressive activities of clotrimazole and gabapentin in a murine malarial model by four-day suppressive test. STUDY DURATION: This study was done between June and December, 2017. METHOD: Clotrimazole (CLT), gabapentin (GBP), com