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Abstract

RP-HPLC METHOD DEVELOPMENT AND VALIDATION FOR DETERMINATION OF PENTAZOCINE IN PARENTRAL DOSAGE FORM

D. Rama Brahma Reddy, R. Rajani*, K. Amaravani, K. Soujanya Shalini and K. Mounika and Kenzeuyile

ABSTRACT

A reverse phase isocratic HPLC was developed and validated for the determination of Pentazocine in bulk and parental dosage forms. Method development was carried out on ODS C18 column 250x4.6mm, particle size 5 μm, maintained at ambient temperature, Shimadzu UFLC-LC 20. The mobile phase was a mixture of Methanol: Phosphate Buffer (68:32 v/v), with apparent pH of 3 and the flow rate was set at 1.0 ml/min and UV detection at 285 nm. The chromatographic retention time of proposed method was 3.96 min and the mean assay of content was found to be 99.30%. After completion of chromatographic separation of pentazocine going to do validation of the drug according to USP. The proposed method was successfully applied for the quantitative determination of Pentazocine in bulk form and could be used for routine analysis with phenomenal accuracy and precisions.

Keywords: Pentazocine, Mobile phase, Validation, Accuracy, precision, Retention time.


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