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World Journal of Pharmacy and
Pharmaceutical Sciences

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical and Medical Research and Technology

Impact Factor : 8.485

ICV : 84.65

WJPPS Citation

	All	Since 2020
Citation	6651	4087
h-index	26	21
i10-index	174	83

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Abstract

EVALUATION OF HEPATOPROTECTIVE ACTIVITY OF SQUALENE ISOLATED FROM ALBIZIA PROCERA AGAINST PARACETAMOL INDUCED HEPATOTOXICITY ON WISTAR RATS

S. Sivakrishnan*, A. Kottai Muthu

ABSTRACT

The aim of this study was to evaluate hepatoprotective activity of squalene isolated from Albizia procera Roxb.(Benth.) against paracetamol induced hepatotoxicity on wistar rats. Paracetamol treatment leads to elevated levels of serum enzymes, non-enzyme markers & lipid profiles and also decreased the serum protein levels. However, treatment with squalene isolated from Albizia procera significantly reversed the above changes compared to the control group as observed in the paracetamol-challenged rats. The results clearly demonstrate that squalene isolated from Albizia procera possesses promising hepatoprotective effects and hence suggests its use as a potential therapeutic agent for protection from paracetamol overdose.

Keywords: Hepatotoxicity, Paracetamol, Albizia procera, Squalene.

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