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Abstract

EVALUATION OF HEPATOPROTECTIVE ACTIVITY OF SQUALENE ISOLATED FROM ALBIZIA PROCERA AGAINST PARACETAMOL INDUCED HEPATOTOXICITY ON WISTAR RATS

S. Sivakrishnan*, A. Kottai Muthu

ABSTRACT

The aim of this study was to evaluate hepatoprotective activity of squalene isolated from Albizia procera Roxb.(Benth.) against paracetamol induced hepatotoxicity on wistar rats. Paracetamol treatment leads to elevated levels of serum enzymes, non-enzyme markers & lipid profiles and also decreased the serum protein levels. However, treatment with squalene isolated from Albizia procera significantly reversed the above changes compared to the control group as observed in the paracetamol-challenged rats. The results clearly demonstrate that squalene isolated from Albizia procera possesses promising hepatoprotective effects and hence suggests its use as a potential therapeutic agent for protection from paracetamol overdose.

Keywords: Hepatotoxicity, Paracetamol, Albizia procera, Squalene.


[Full Text Article]

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