Abstract

DEVELOPMENT AND EVALUATION OF SUSTAINED RELEASE MATRIX TABLETS OF LOSARTAN POTASSIUM BY USING NATURAL AND SYNTHETIC POLYMERS

Sidram Arawattu, P. Ashok Kumar*, Mancy S. P. and Suresh V. Kulkarni

ABSTRACT

The objective of the study was to develop a sustained release matrix tablets of Losartan potassium, an antihypertensive drug. The sustained release tablets were prepared by wet granulation and formulated using drug and different polymer ratios, nine different formulations were prepared from F1 to F9. Hydrophilic polymer & hydrophobic polymer like natural polymer like Xanthan Gum (XG), Guar Gum, and Karaya gum were used. Compatibility of the drug with various excipients was studied by using FTIR and DSC. The compressed tablets were evaluated for compliance with Pharmacopoeia limits. The formulation (F1) is optimized on the basis of acceptable tablet properties and in vitro drug release. The resulting formulation produced robust tablets with optimum hardness, consistent weight uniformity and friability. The results of dissolution studies indicated that formulations F1, F2 & F3 have shown better drug release profile than compared other formulations. Among all other formulations the formulation F1 (drug to polymer 1:1) was found to be the most successful and the study exhibited sustained release of Losartan potassium with 96.45% released at the end of 24 hours. A decrease in release kinetics of the drug was observed on increasing polymer ratio. Applying exponential equation, all the formulation tablets (except F1) showed diffusion-dominated drug release. The drug release kinetics was found to be Non-Fickian super case II

Keywords: Losartan Potassium, Xanthan gum, Sustained release, Matrix Tablets.