Abstract

SOLID LIPID NANOPARTICLE: A NOVEL APPROCHES OF DRUG DELIVERY SYSTEM

Pravesh Dubey*, Mohd. Asad Farooqui, Roohi Kesharwani and Harshit Shukla

ABSTRACT

Lipid nanoparticles were developed in the last decade of the last century as alternative carrier system to emulsions, liposomes and polymeric nanoparticles. Solid lipid nanoparticles (SLN) and nanostructured lipid carriers (NLC) are the two main types of lipid nanoparticles. The present review focuses on the utility of SLN in terms of their advantages, production methodology, characterization and applications. Due to their unique size-dependent properties, lipid nanoparticles offer the possibility to develop new therapeutics. The ability to incorporate drugs into nano carriers offers a new prototype in drug delivery that could use for drug targeting. Hence solid lipid nanoparticles hold great promise for reaching the goal of controlled and site specific drug delivery and hence attracted wide attention of researchers. This review presents a broad treatment of solid lipid nanoparticles discussing their aims, production procedures, advantages, limitations and their possible remedies.

Keywords: Solid lipid nanoparticle, liposome, polymeric, emulsion.