Abstract

HEPATORENAL PROTECTIVE EFFECT OF CURCUMIN IN NORMAL AND INFECTED RATS WITH STAPHYLOCOCUSS AUREUS TREATED WITH AZITHROMYCIN

*M. G. A. EL. Sayed, Enas A. H. Farag and Mona Y. M. Kandil

ABSTRACT

The aim of this study was to determine the adverse effects of therapeutic dose of azithromycin 45 mg /kg body weight for 5 days in normal, and infected rats with staphylococcus aureus on liver and kidney functions. Forty five male Wister albino rats were randomly divided into main five groups including Group(1): control(normal saline only 0.2ml). Group (2):rats treated with azithromycin orally(45 mg/kg b.wt) for 5 successive days. Group (3): rats were infected with Staphylococcus aureus. Group (4): rats were infected with Staphylococcus aureus and treated with azithromycin (45 mg/kg b.wt) daily for 5 successive days. Group (5): rats were infected with Staphylococcus aureus and treated with azithromycin orally (45 mg/kg b.wt) plus curcumin (20mg/kg b.wt) daily for 5 successive days. Treatment with azithromycin showed a significant (P

Keywords: azithermycin –curcumin-biochemical-histopathological.