Abstract

SYNTHESIS, CHARACTERIZATION AND ANTI BACTERIAL ACTIVITY OF COUMADIN DERIVATIVES

M. Sukanya*, Meera Devi, Kalyani, Dr N. Padmalatha

ABSTRACT

A number of natural and synthetic coumarin derivatives have been reported to exert notably antimicrobial activity. Starting from 7- hydroxy-4-methyl coumarin which was prepared via pechmann condensation, some coumarin derivatives were synthesized by mannich reactions. The synthesized compounds were 8- ((dimethylamino)methyl-7-hydroxy-4-methyl coumarin, 8- ((diethylamino)methyl-7-hydroxy-4-methyl coumarin, 7-hydroxy-4- methyl-8-(piperidin-1-yl methyl)-coumarin,7-hydroxy-4-methyl-8- (morpholinomethyl)-coumarin, 8-((dimethylamino)methyl-7-ethoxy-4- methyl coumarin, 8-((diethylamino)methyl-7-ethoxy-4-methyl coumarin, 7-ethoxy-4-methyl-8-(morpholino methyl)-coumarin. The prepared compounds were evaluated for their antimicrobial activity against gram positive bacteria Bacillus subtilis, Staphylcoccus aureus and Gram negative bacteria Pseudomonas aeruginosa, Escherichia coli.

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