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Abstract

ROLE OF TRANSIENT RECEPTOR POTENTIAL V1 CHANNEL (TRPV1) IN ENALAPRIL INDUCED HYPERALGESIA: A PRELIMINARY STUDY

*Priyanshee Gohil, Vijay Rafalia, Gaurang Shah

ABSTRACT

Transient receptor potential vanilloid type-1 (TRPV1) activated by various inflammatory mediators; plays a key role in occurrence of hyperalgesia. Enalapril, an Angiotensin converting enzyme (ACE) inhibitor, suggested for its hyperalgesic effect in preclinical and clinical studies. Therefore, present investigation is carried out to find out the role of TRPV1 in enalapril induced hyperalgesia using diabetic mice model. Enalapril showed a significant decrease in nociceptive threshold as compared to diabetic control group, while there was a significant increase in reaction time, tail flick latency and tail withdrawal latency, in the animals pre-treated with capsazepine, before 2 h of enalapril administration as compared to enalapril treated diabetic group at day 10. TRPV1 might be involved in enalapril induced hyperalgesia.

Keywords: Enalapril, hyperalgesia, TRPV1, diabetes mellitus, nociceptive threshold.


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