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*Naisarg D. Pujara1, Namrata V. Patel2 Ankita P. Thacker3, Brahmdutta K. Raval4, Sumit M. Doshi1, Ramesh B. Parmar1

1Department of Pharmaceutics, S. J. Thakkar Pharmacy College, Rajkot 360 005, Gujarat, India.
2Department of Pharmacy, Faculty of Technology and Engineering, Vadodara 390 001, Gujarat, India.
3Department of Pharmaceutics, K. B. Raval College of Pharmacy, Gandhinagar 382 423, Gujarat, India.
4Department of Pharmaceutics, N. R. Vekaria Institute of Pharmacy, Junagadh - 362001, Gujarat, India.


The purpose of writing this review on floating microspheres was to compile the recent literature with special focus on the principal mechanism of floatation to achieve gastric retention. Recent advances indicate that floating microspheres are especially suitable for achieving sustained or delayed release oral formulations with flexibility of blending to attain different release patterns, low risk of dose dumping as well as reproducible and short gastric retention time. One of the approaches toward this goal is to develop the floating microspheres so as to increase the gastric retention time. The development of floating microspheres involves different solvent evaporation techniques to create the hollow inner core. In this review, the current status of floating microspheres including hollow microspheres (micro balloons) and their characterization, advantages, disadvantages, application, mechanism and method of preparation for gastric retention of drug are discussed. This review also summarizes the in vitro and in vivo studies to evaluate the performance and applications of floating microspheres. These systems are useful to encounter several difficulties during the development of pharmaceutical dosage form.

Keywords: Floating microspheres, Floating Drug Delivery System, Gastro Retention, Bioavailability, Hydro dynamically Balanced Systems.

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