FLOATING MICROSPHERES: A NOVEL APPROACH FOR GASTRO RETENTION
*Naisarg D. Pujara1, Namrata V. Patel2 Ankita P. Thacker3, Brahmdutta K. Raval4, Sumit M. Doshi1, Ramesh B. Parmar1
1Department of Pharmaceutics, S. J. Thakkar Pharmacy College, Rajkot – 360 005, Gujarat, India.
2Department of Pharmacy, Faculty of Technology and Engineering, Vadodara – 390 001, Gujarat, India.
3Department of Pharmaceutics, K. B. Raval College of Pharmacy, Gandhinagar – 382 423, Gujarat, India.
4Department of Pharmaceutics, N. R. Vekaria Institute of Pharmacy, Junagadh - 362001, Gujarat, India.
ABSTRACT
The purpose of writing this review on floating microspheres was to
compile the recent literature with special focus on the principal
mechanism of floatation to achieve gastric retention. Recent advances
indicate that floating microspheres are especially suitable for
achieving sustained or delayed release oral formulations with
flexibility of blending to attain different release patterns, low risk of
dose dumping as well as reproducible and short gastric retention time.
One of the approaches toward this goal is to develop the floating
microspheres so as to increase the gastric retention time. The
development of floating microspheres involves different solvent
evaporation techniques to create the hollow inner core. In this review,
the current status of floating microspheres including hollow
microspheres (micro balloons) and their characterization, advantages,
disadvantages, application, mechanism and method of preparation for
gastric retention of drug are discussed. This review also summarizes the in vitro and in vivo
studies to evaluate the performance and applications of floating microspheres. These systems are useful to encounter several difficulties during the development of pharmaceutical dosage
form.
Keywords: Floating microspheres, Floating Drug Delivery System, Gastro Retention, Bioavailability, Hydro dynamically Balanced Systems.
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