Abstract

FORMALDEHYD CONTENT DETERMINATION BY GC AS DERIVATIZATION WITH PTSA

T. Naga Jhansi*, G. Nageswara Rao, D. Pavan Kumar and D. Jaya Deep Kumar

ABSTRACT

This GCHS method describes, developed and validated method for the quantification of formaldehyde in residual solvents. Method was developed on AT-WAX- 30mx 0.53mm id, 1.0μm column, with a flame ionization detector. Split ratio as 1:1 and oven program as initially held at 40°C for 5 min then increased to 230°C at the rate of 35°C per min and held at 230°C for 15 min. Method is identified as linear in the range 0.4 ppm to 3.0 ppm. Minimum quantification level for this method achieved as 0.4 ppm, whereas the minimum detection level for the formaldehyde was 0.2 ppm. Method is validated as per the ICH guidelines.

Keywords: Formaldehyde, Para toluene sulphonic acid, GCHSS, FID detector, Validation.