Abstract

A COMPARATIVE ANALYSIS OF CHITOSAN BASED DESENSITIZING AGENT WITH GLUMA, IN REDUCING DENTINE HYPERSENSITIVITY - A RANDOMIZED CONTROLLED TRIAL

Dr. Naz-E-Farha Hakeem*, Dr. Shruthi Eshwar, Dr. B. K. Srivastava, Dr. Vipin Jain and Dr. Sudarshan Chinna

ABSTRACT

Introduction: Dentinal hypersensitivity (DH) is a common clinical condition usually associated with exposed dentinal surfaces, which often resolves with the natural sclerotic obturation of dentinal tubules. Chitosan, a natural biopolymer which has excellent properties like biocompatibility, anti inflammatory, bio-adhesive which makes it suitable for treating dentine hypersensitivity, though commonly used desensitizers like gluma have many advantages, exhibit certain adverse effects like acute toxicity, skin corrosions, respiratory sensitizations. Objective: To compare the effectiveness of chitosan hydrogel and GLUMA (glutaraldehyde containing desensitizer) in reducing dentin hypersensitivity. Methodology: A randomized, single-blind, split mouth clinical trial was conducted on 30 patients aged 18–60 years who were suffering from dentinal hypersensitivity in relation to canine, premolar and molars with erosion, abrasion, and gingival recession were randomly enrolled. Response to tactile stimuli were measured using visual analogue scale initially on baseline, after intervention and final assessment was done on the 15th day. Desensitizing agents used were GLUMA desensitizer and chitosan hydrogel. Baseline sensitivity scores after tactile stimuli were recorded following which desensitizing agents were applied sensitivity scores were recorded. The data was analyzed using paired t-test, repeated measure ANOVA was used for multiple comparisons at different time interval. (P < 0.05 was considered statistically significant). Result: There was significant reduction in VAS score from baseline to 15th day in both the groups. Chitosan hydrogel showed significant reduction in hypersensitivity scores at different time interval (P < 0.001). Conclusion: Gluma and Chitosan Hydrogel both are potential desensitizer.

Keywords: Dentine hypersensitivity, chitosan hydrogel, VAS scale.