Abstract

A REVIEW ON SOLID LIPID NANOPARTICLES: AS A PROMISING APPROACH FOR TARGETED DRUG DELIVERY SYSTEM

Parikshit Dhanu Shirure*, Mahewash Asadulla Pathan, Priyanka Ramesh Surwase, Manjusha Shivkumar Kareppa

ABSTRACT

Nanoparticles are solid colloidal particles ranging in size from 1 to 1000 nm and composed of macromolecular material. Nanoparticles could be polymeric or lipidic (Solid Lipid Nanoparticles). Industry estimates suggest that approximately 40% of lipophilic drug candidates fail due to solubility and formulation stability issues, prompting significant research activity in advanced lipophilic delivery technologies. Solid lipid nanoparticles (SLN) are most developing formulations of nanotechnology with several applications in different fields like drug delivery, clinical medicine and research as well as in other varied sciences. SLN are defined as the spherical particles of nanometer range which immersed in water or aqueous surfactant solution either using lipophilic and hydrophilic drug. Solid lipid nanoparticle technology represents a promising new approach to lipophilic drug delivery. The bioacceptable and biodegradable nature of SLNs makes them less toxic as compared to polymeric nanoparticles. Supplemented with small size which prolongs the circulation time in blood, feasible scale up for large scale production and absence of burst effect makes them interesting candidates for study. In this present review this new approach is discussed in terms of their advantages, disadvantages, preparation methods, characterization and special features and their applications. And it was found that, if properly investigated, SLNs may open new vistas in therapy of complex diseases.

Keywords: Solid lipid nanoparticles (SLN), colloidal drug carriers, homogenization, Targeted drug delivery.