Abstract

A REVIEW WITH SPECIAL PROMINENCE ON MUCOADHESIVE BUCCAL DRUG DELIVERY FOR PEPTIC ULCER

Raoof Ali*, Disha Dutta and Ashok Kumar

ABSTRACT

Around the novel drug delivery system such as a mucoadhesive and buccal system has made accessible a lot of beneficial in the field of pharmacy. Mucoadhesive buccal drug delivery systems are novel drug delivery system, which utilize the property of bioadhesion of polymers that happen to adhere on hydration, these drug delivery system can be used for targeting a drug to the exacting region of the body for an extended period of time. Mucoadhesion is an interfacial process in which polymers bind to the mucus through the covalent bond, and the polymers act as a drug delivery vehicle in the mucoadhesive drug delivery system. Peptic ulcer is a chronic developmental disease in human, in which imbalance take place between aggressive factor and defensive factor resulting erosion of the lining of the stomach, or the upper duodenum. It has been mostly established diseases in the world and it has a multifactor etiology. Some environmental elements such as spicy food, warring lifestyle, alcohol and nicotine can increase the acid and bicarbonate secretion and these factors inhibit or reduce the secretion of mucus in the digestive tract.

Keywords: Mucoadhesive buccal drug delivery system, bioadhesion, polymer, peptic ulcer.