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Dr. Jayapal Reddy Gangadi*, Dr. Sanjeev Kumar Subudhi, L. Sheethal, G. Anil reddy, V. Vaishnavi and L. Reethu


The objective of the present work was to formulate floating hollow microspheres of Ranolazine which is soluble and shows better absorption in gastric pH. Microspheres were prepared by emulsion solvent diffusion technique. Using various such as sodium alginate, HPMC, and eudragit polymers. The formulations were evaluated for micromeritic properties, buoyancy, % yield, entrapment efficiency and in vitro studies. They were characterized by FT-IR. FT-IR and studies indicated that there was no interaction between the drug and polymers. SEM photographs showed the outer surface of microspheres was smooth and dense where as internal surface was porous which helped to prolong floating to increase residence time in stomach. The results showed that floating microspheres could be successfully prepared with better yield. Results showed larger the particle size, longer was the floating time. In vitro drug release studies showed controlled release of Ranolazine for over 8 h. From the results it can be concluded that gastric floating hollow microspheres can be successfully used for the delivery of Ranolazine maleate to control blood glucose level.

Keywords: Ranolazine, Polymers, Ionotropic gelation technique, floating time, in vitro drug release studies.

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