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Dr. Jayapal reddy Gangadi*, Dr. Sanjeev Kumar Subudhi, T. Sameera Devi, Ch. Akhila, Sushma, M. Sandeep and D. Arun kumar


The objective of present study was to develop matrix type buccal patch therapeutic systems of Doxofylline using sodium alginate, ethylcellulose, and hydroxypropyl methylcellulose in various proportions and combinations were fabricated by solvent casting technique. Various physicomechanical parameters like weight variation, thickness, folding endurance, drug content, moisture content, moisture absorption, in vitro drug release studies were evaluated. An in vitro drug release study was designed, and it was carried out using commercial semipermeable membrane. The F4 formulation was found to be stable as there was no drastic change in the Physico-chemical properties of the patches. F1, F2, F3, F4 formulations showed highest cumulative percentage drug release of 97.35%, 95.35%, 94.26%, 98.60%. were obtained during in vitro drug release studies after 20 hrs. The release of Doxofylline appears to be dependent on lipophilicity of the matrix. Moderately lipophillic matrices showed best release. The predominant release mechanism of drug through the fabricated matrices was believed to be by diffusion mechanism. Based upon the in vitro dissolution data the F4 formulation was concluded as optimized formulation.

Keywords: Buccal delivery system, Natural and synthetic polymers, solvent casting technique, Diffusion mechanism.

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