Abstract

FEBUXOSTAT INHIBITS CONCANAVALIN A INDUCED ACUTE HEPATIC INJURY IN MICE AS INDICATED BY DECREASING THE INCREASED SERUM TRANSAMINASE, TOTAL BILIRUBIN AND ALBUMIN

Mohammed M. Maresh*, Rania R. Abdelaziz and Tarek M. Ibrahim

ABSTRACT

Effect of febuxostat administration on acute liver injury induced by concanavalin A injection into mice eye orbital sinus was studied in the present work. Oral administration of febuxostat either 1 hours before administration of Con A or ½ hour after administration of Con A both significantly inhibited the increase of serum ALT, AST, total bilirubin, and the decrease of serum albumin induced by Con A. These results indicate that febuxostat may be an effective inhibitor of the immune reaction that results from Con A administration into mice.

Keywords: Acute Hepatic Injury, Concanavalin A, Febuxostat.