Abstract

EVALUATION OF IN VITRO ANTICANCER ACTIVITY OF STEMBARK EXTRACTS OF PLANT MAYTENUS EMARGINATA

Umesh Prabhakar Joshi* and Rajendra Dayaram Wagh

ABSTRACT

Cancer is a major public health problem in all over the world. Medicinal herbs have been always on the forefront whenever we talk about anticancer properties. Many herbal plants have been evaluated and are currently being investigated phytochemically to understand their anticancer actions against various types of cancers. The aim of the present study is to evaluate the effect of in-vitro anticancer activity of extracts. The petroleum ether, chloroform, methanolic, aqueous and hydroalcoholic extract of stembark of plant Maytenus emarginata against five human cancer cell lines such as Cervical cancer cell lines (Hela), Colon cancer cell lines (Colo-205), Lung cancer cell lines (A-549), Prostate cancer cell lines (PC-3) and Breast cancer cell lines (MCF-7) and it was compared with Adriamycin as Positive control compound by using Sulforhodamine B (SRB) assay. Anticancer activity of Chloroform and Methanolic extract of plant Maytenus emarginata on Hela, Colo-205, A-549, PC-3 and MCF-7 cancer cell lines showed potent cytotoxic activity as compared to other extracts. The results of the present work may be beneficial for the development of anticancer agents of plant origin.

Keywords: Adriamycin, Maytenus emarginata, In-vitro anticancer activity, Human cancer cell lines, Sulforhodamine B (SRB) assay etc.