Abstract

HEPATO PROTECTIVE EFFECTS OF SVENSONIA HYDERABADENSIS L. WHOLE PLANT ETHANOLIC EXTRACT AGAINST PARACETAMOL INDUCED LIVER DAMAGE IN RAT

Nusrath Yasmeen*, G.Usha Kiran mai , T.Pradeep kumar, T.Lavanya, Devender Kodati 

ABSTRACT

Liver is a vital organ of human body; it has been exposed to various hepatotoxicants (xenobiotics) in our day to day life of modernization especially in the developing countries. Despite of considerable progress in the treatment of liver damage by oral hepatoprotective agents, much attention has been focused on plant derived drugs because synthetic drugs have several limitations. Ethanolic extract of Svensonia hyderobadensis of (ESH, 200 and 400 mg/kg, p.o.) was evaluated for prophylactic and therapeutic hepatoprotective activity against Paracetamol induced hepatic damage. Silymarin (100 mg/kg, p.o.) was used as standard drug. Hepatoprotective activity was assessed by biochemical markers viz, AST, ALT, ALP, total bilirubin, direct bilirubin, and histopathological examination of liver sections. Alteration in the levels of biochemical markers of hepatic damage like AST, ALT, ALP, bilirubin were studied in both treated and untreated groups. Paracetamol (2 g/kg, bw. p.o,) has enhanced the SGPT, SGOT, ALP, bilirubin. Treatment with ethanolic extract of Svensonia hyderobadensis 200&400 mg/kg, bw. p.o,) brought back the altered levels of biochemical markers to the near normal levels in the dose dependent manner. Histological examination of the liver tissues confirmed the hepatoprotective effect of Svensonia hyderobadensis .And therefore, it was concluded that the ethanolic extract of Svensonia hyderobadensis root possesses commendable hepatoprotective activity.

Keywords: Hepatoprotective, Svensonia hyderobadensis, paracetamol, AST, ALT, ALP, bilirubin.