Abstract

ANTI-HYPERLIPIDEMIC ACTIVITY OF TRICHOPUS ZEYLANICUS LEAVES AGAINST HIGH FAT DIET AND TRITON X- 100 INDUCED HYPERLIPIDEMIA

M.VishnuVardhan Reddy, *A.Rajani, S.Nikitha, Jincy Thomas, K.Hemamalini

ABSTRACT

Hyperlipidemia is the greatest risk factor of coronary heart disease. Currently available hypolipidemic drugs have been associated with number of side effects. Herbal treatment for hyperlipidemia has no side effects and is relatively cheap and locally available. A literature claims that flavonoids can able to reduce the hyperlipidemia. The literature available on Trichopus zeylanicus suggested for the presence of flavonoid content, therefore the leaves of Trichopus zeylanicus were selected and the present study was designed to investigate theanti-hyperlipidemic activity of methanolic extract of Trichopus zeylanicus in High Fat Diet & Triton X-100 induced Hyperlipidemia. Trichopus zeylanicus was administered at a dose of 200mg/kg and and 400mg/kg per day, (p.o) to High Fat Diet &Triton induced Hyperlipidemic rats. Lovastatin was used as reference standard.The statistical analysis was carried out using one way ANOVA followed by Dunnett’s t-test. Trichopus zeylanicus showed a significant decrease in the levels of serum cholesterol, triglycerides, LDL, VLDL and a gradual increase in the level of serum HDL at the dose of 400mg/kg/day (p.o) against High fat diet &Triton induced hyperlipidemia. Therefore the study concluded that the methanolic extract of leaves of Trichopus zeylanicus effectively suppressed the hyperlipidemia in rats, suggesting the potential protective role in Coronary heart disease.

Keywords: Trichopus zeylanicus, Hyperlipidemia, Triglycerides, lipoprotein, High fat diet, Triton X-100.