Abstract

EXTRACTION, INVITRO SCREENING AND PREPARATION OF TABLETS FROM DRAGON FRUIT PARTS

E. Lakshmi* and Dr. M. Sunitha Reddy

ABSTRACT

Background: The dragon fruit is an epiphyte which belongs to the family Cactaceae. The botanical name of dragon fruit is called hylocereus undatus. The aim of the study is to prepare the tablets and evaluate Invitro screening tests by using the dragon fruit part extracts as a binder. The study focuses on the comparison of different concentrations of the binder with the synthetic binder and marketed tablets. Methods: The different extracts obtained from the fruit are subjected to various tests like phytochemical screening for the presence of phenolic compounds. The other Invitro screening tests are performed to check the antioxidant and antibacterial activities. The micro dilution method and agar cup plate method were used to study the antibacterial property. The DPPH method was performed to study the antioxidant property. Results: The pulp extract and seed extract showed good antibacterial activity. The seed extract showed the high inhibition percentage in antioxidant activity. Finally the tablets were punched after performing the above various tests by using various concentrations of fruit extract along with the API Naproxen and other Excipients. The evaluation tests were performed as per the guidelines of I.P. The drug release profiles of extracts of pulp 5% and pulp 10% showed the good dissolution rate which is almost nearer to standard drug Naproxen. Conclusion: Finally ,all the tablets with varying concentrations are compared with marketed drug Naproxen and found that the dragon fruit extract is showing binding property and can be used as natural binder instead of synthetic binder and can also be used for the sustained release formulations in the upcoming future.

Keywords: Dragon fruit, DPPH, Antibacterial activity, Antioxidant activity, Naproxen, Natural binder, Sustained release.