COW GHEE AS A BASE FOR DICLOFENAC SODIUM SUPPOSITORIES
*Dinesh M. Biyani1, Priya Ranjan Prasad Verma1, Chandrashekhar A. Doifode2, Avinash K. Dorle3
1Department of Pharmaceutical Sciences, Birla Institute of Technology, Mesra, Ranchi,Jharkhand, India.
2Sachchidanand Institute of Pharmacy, Koradi, Nagpur, Maharashtra, India.
3“Gitai”, 43, Ramnagar, Nagpur – 440010, Maharashtra, India.
ABSTRACT
Suppositories are solid dosage forms intended for administration of
medicine via the rectum, vagina or urethra that melt, soften or
dissolve in the body cavity. They generally weigh approximately 1-2
gm and are about 1-1.5 inches long. Suppositories are indicated for
administering the drugs to infants & younger children, severely
debilitated patients or those who can not take medicines orally. Drugs
through rectal route can be given for local or systemic purposes.
Types of bases used for suppositories are Coca butter & other
synthetic fatty bases, water soluble or dispersible bases and
glycerinated gelatine bases. In the present investigation an attempt has
been made to formulate diclofenac sodium suppositories
incorporating ancient medicinal formulation excipient i.e. cow ghee.
Suppositories were prepared using cow ghee and other bases and
prepared suppositories were evaluated for their melting range,
hardness, drug content and drug release. It was found that cow ghee and PEG combination
bases gave best release patterns as well other characteristics. It can thus be concluded that
cow ghee being an endogenous substance could be better alternative for such dosage forms,
but require further investigations.
Keywords: Suppository, Cow ghee, Diclofenac sodium.
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