Abstract

A REVIEW ON SUBLINGUAL IMMUNOTHERAPY FOR THE TREATMENT OF ASTHMA, ALLERGIC RHINITIS AND CONJUNCTIVITIS

M. Pramod Kumar*, D. Prathibha, G. Ravi Teja, K. Keerthana and S. K. Mymoonissa

ABSTRACT

Allergen specific immunotherapy is aimed at modifying the natural history of allergy by inducing tolerance to the causative allergen. Sub-cutaneous immunotherapy has a major flow in side effect, especially in possible anaphylactic reaction, and this prompted the search for safe ways of administration of allergen extracts. SLIT has met such need while maintaining a clinical efficacy comparable to SLIT. The systematic revision of the available literature was substantially free from serious systemic reaction. A number of Meta analysis clearly showed that SLIT is effective in allergic rhinitis by significantly reducing the clinical symptoms and the use of anti-allergic drugs. Beside the efficacy on symptoms, the preventive activity and the cost effectiveness are important outcomes of SLIT in asthma. The need to meet included more data on the efficacy in the house dust mist might asthma optimal techniques of Administration and as previously done with SLIT introduction of adjuvants able to enhance the immunological response and use of Recombinant allergens.

Keywords: Asthma, Allergic Rhinitis and Conjunctivitis.