Abstract

MONITORING THE QUALITY OF ANTIBIOTICS: POTENTIAL TESTS AND TESTS COMPARISON OF ANTIBIOTIC DOXYCYCLINE USED IN CASES OF ANTIBIOTIC RESISTANCE IN ACUTE RESPIRATORY INFECTION DISEASE

Danni Ramdhani*, Sri Agung F. K. and Amalia Octa Permatasari

ABSTRACT

Objective: Acute respiratory infection (ARI) is a disease of the upper and lower respiratory tract and is usually contagious and can cause various spectrums of disease caused by viruses, bacteria, rickettes. Doxycycline antibiotics are one of the antibiotics commonly used to treat ARI. The use of antibiotics that are of less quality and can cause treatment is less effective and can cause resistance. This study aims to determine the potential value and comparative test of tetracycline antibiotics as a quality evaluation. Methods: Test the antibiotic potency with diffusion method to use 3 doses with using antibiotic samples. Comparative test of antibiotic testing by comparing samples with standard against Staphylococcus aureus ATCC 29213 test bacteria. Results: The potential value obtained was 86.8%, and comparative test was 1 : 1.03. Conclusion: Potential antibiotic test results indicate that the potential value of the doxycycline antibiotic used has decreased from the provisions listed in Indonesian pharmacopoeia 88 - 98%.

Keywords: Doxycycline, antibiotic resistence, potential test, comparative test, agar diffusion.