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Abstract

QUALITATIVE SCREENINGS OF PHYTOCHEMICALS AND ANTIHYPERGLYCAEMIC ACTIVITY ON LEAVES OF URTICA DIOICA USING STEPTOZOTOCIN INDUCED DIABETIC MICE MODEL

*Dr. Vijay Nigam, Dr. Manoj Kumar Mishra and Pramod Kumar Biswal

ABSTRACT

Objective: To study the anti hyperglycaemic effect of aqueous extract of the leaves of Urtica dioicia streptozotocin (STZ) induced diabetic mice. The leaves extract of Urtica dioicia doses 100 and 200 mg/kg b.w was administered for 21 days and blood glucose level, serum cholesterol, liver glycogen was estimated. Treatment of the Streptozotocin induced diabetic mice with the leaves extract resulted in significant reduction of blood glucose level (P<.0001), serum cholesterol (P<.01) and increase in liver glycogen (P<.0001). The results suggest that the leaves extract of Urtica dioica possess anti hyperglycaemic effect in Streptozotocin induced diabetic mice which justify the traditional use of this plant as ethnomedicine in treatment of diabetes.

Keywords: Urtica dioicia, Antihyperglycaemic, Diabetes mellitus, Streptozotocin, Oral administration.


[Full Text Article]

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