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R. Ananth Kumar, A. Rama Devi, P. Sathya Narayana*, J. China Babu and T. Anil Krishna


Quetiapine is among the most widely used atypical antipsychotics, and has the least propensity to induce extrapyramidal motor symptoms. The main objectives of this work is to develop extended release matrix tablets of Quetiapine fumarate using different polymers viz. Carbopol, glyceryl behenate and vegetable oil. Varying ratios of drug and polymer like were selected for the study. After fixing the ratio of drug and polymer for control the release of drug up to desired time, the release rates were modulated by combination of two different rates controlling material and triple mixture of two different rate controlling material. The coating was done by Ethylcellulose as a film former and opadry yellow as coloring agent. After evaluation of physical properties of tablet, the in vitro release study was performed in 0.1 N HCl pH 1.2 for 2 hrs and in phosphate buffer pH 6.2 up to remaining hours. The effect of polymer concentration and polymer blend concentration were studied. Among all the formulations, Quetiapine Fumarate Extended matrix tablets F006 which contains carbopol release the drug which follows Zero order kinetics, and the release profile of formulation of Quetiapine Fumarate Extended release matrix tablets of F006 was comparable with marketed product. Stability studies (40±2ºC/75±5%RH) for 3 months indicated that Quetiapine fumarate was stable in the matrix tablets.

Keywords: Absorption, Bioavailability, concentration time, Extended release, Gastrointestinal.

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