Abstract

A REVIEW OF BIOLOGICAL POTENTIAL OF PYRAZINE AND RELATED HETEROCYCLIC COMPOUNDS

Baldwin Mathew V*, Sonia D Arikkatt, Sindhu T J, Meena Chanran, Bhat A R, Krishnakumar K

ABSTRACT

Plan: A review on the importance of pyrazine and related heterocyclic compounds for tuberculosis and other conditions. Pyraines shows various biological activities such as antimycobacterial, antibacterial, fungicidal etc. Pyrazinamide, a derivative of pyrazine is an important antitubercular agent used as first line drug for tuberculosis therapy. Tuberculosis is a chronic granulomatous disease caused by Mycobacterium tuberculosis. The major problem in tuberculosis therapy is the development of drug resistance. In the present study, we have made an attempt to compile the reports on biological potential of pyrazine and related heterocyclic compounds. These compounds possess good antimicobacterial, antibacterial, antifungal, cytotoxic and oxidant activities. Thus pyrazine can be used for the development of new chemical entities to treat Mycobacterial infection and various other conditions.

Keywords: Pyrazine, Pyrazinamide (PZA), Antimycobacterial, Antibacterial, Antifungal.